Progress in Epidermolysis Bullosa Research: Toward Treatment and Cure

Progress in Epidermolysis Bullosa Research: Toward Treatment and Cure

Jouni Uitto, John A McGrath, Ulrich Rodeck, Leena Bruckner-Tuderman and E Clare Robinson

Abstrat

Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of blistering disorders with considerable morbidity and mortality. Two decades ago, EB entered the molecular era with the identification of mutations in specific genes expressed within the cutaneous basement membrane zone; mutations in 14 genes have now been identified. This progress has now formed the basis for development of novel molecular therapies for this disease.

Journal of Investigative Dermatology 130 , 1778-1784 (July 2010) | doi:10.1038/jid.2010.90